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General caution is advised in patients with extreme renal impairment, particularly in those with comorbidities. If the Examiner believes this to be the case, the applicant should be given a couple of days to get well and then be retested. Macroscopic and histological features had been scored and in contrast with 30 developmentally regular (non-inflammatory bowel disease, non-coeliac illness) controls (median age 7 years; vary 1-11; 25 male) exhibiting mild non-specific colitis in 16 instances (13 male) and normal colonic histology in 14 circumstances (12 male) treatment 31st october order 35 mg residronate with amex.